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    • ER Stress Disorders/Diabetes Requisition
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Wolfram syndrome
​global AWARENESS DAY

October 1, 2025
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Empowering clinicians and patients to Identify and Treat 

​WOLFRAM SYNDROME


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Awareness:
The key to 
​diagnosing and treating 
Wolfram syndrome 
and Other ER stress diseases

The Power of Wolfram syndrome
Wolfram syndrome is an ultra-rare genetic disorder. Its constituent medical components (diabetes mellitus, deafness, retinal degeneration, neurodegeneration) and underlying Endoplasmic Reticulum (ER) pathophysiology are individually present in many common diseases. Novel treatments designed for WS may have broader implications for other medical conditions characterized by ER stress and dysfunction.

By leveraging tools and therapeutic efforts targeting Wolfram syndrome, Clinicians can identify and treat Wolfram syndrome, and researchers may identify novel treatment modalities for more prevalent disorders such as diabetes mellitus and neurodegenerative diseases. 
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Learn More

Specialties Diagnosing Wolfram Syndrome

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Endocrinology
  • Diabetes
  • Hyperglycemia
  • ​Diabetes Insipidus 
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Ophthalmology
  • Color Blindness
  • Decreased Visual Acuity
  • Decreased Pupillary Reflex
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Neurology
  • Ataxia
  • Dysphagia
  • Autonomic Dysfunction
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Urology
  • Incontinence
  • UTI
  • Voiding dysfunction
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Genetics
  • Autoantibody negative diabetes
  • Familial diabetes/ONA
  • Identification of classic phenotype
WS Clinical Guidelines

Consider
​Wolfram Syndrome

Presenting symptoms of Wolfram syndrome are common, including but not limited to:
  • diabetes (antibody negative)
  • ​decreasing visual acuity
  • loss of color vision
  • deafness
  • ​ataxia

By following WS Clinical Guidelines, a more rapid diagnosis is possible and WS specific treatment can be initiated.
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 Implementation and planning headed by WSUK 
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with support from
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Wolfram Syndrome Germany
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  • Home
  • About WS
  • For Clinicians
    • Endocrinology
    • Neurology
    • Ophthalmology
    • Urology
    • Psychiatry/Mental Health
    • Clinical Trials
    • Consider Wolfram Syndrome
    • Wolfram Syndrome Clinical Guidelines
    • ER Stress Disorders/Diabetes Requisition
  • Treatment
    • Treatment Strategies
    • Treatment Pipeline
    • Wolfram Syndrome Clinical Guidelines
    • Clinical Trials
  • For Patients
  • Clinical Trials
  • Donate
  • Contact
  • More Information
    • Connect to WS Research
    • WS Patient Registries